Amycretin, developed by Novo Nordisk, is a single-molecule long-acting GLP-1 and amylin receptor agonist. Its mechanism of action achieves weight loss by simultaneously activating both receptors: • GLP-1 receptor activation: delays gastric emptying, promotes insulin secretion, and lowers blood sugar; • Activation of amylin receptors: It directly acts on the central nervous system, inhibits appetite and reduces energy intake. In July 2025, the molecular structure of Amycretin, a GLP-1 series product under Novo Nordisk, was officially disclosed.

The amycretin structure comprises a GLP-1 receptor agonist moiety (dark blue) and an amylin receptor agonist moiety (light blue) connected by a linker region (yellow). The amycretin peptide is acylated with a C18 diacid-based sidechain (white) at position K37 (when employing GLP-1 7-37 numbering). Aib, α-aminoisobutyric acid; Ala, alanine; Arg, arginine; Asp, aspartic acid; C, carbon; Gln, glutamine; GLP-1, glucagon-like peptide-1; Glu, glutamic acid; Gly, glycine; H, hydrogen; His, histidine; Ile, isoleucine; K, lysine; Leu, leucine; Lys, lysine; N, nitrogen; O, oxygen; OH, hydroxyl group; Phe, phenylalanine; Pro, proline; Ser, serine; Thr, threonine; Trp, tryptophan; Tyr, tyrosine; Val, valine.

Anyone need to enquire about the peptide raw materials, plz contact:
haoran.tse@gmail.com
+8618575536586

The synthesis of GLP-1 impurities is difficult. Now in China domestic market, generally impurities are provided by professional CRO which focus on peptide impurities.
Anyone need to know more, plz download the impurities list below.

GLP-1 impurities.xlsx
You can also contact me
Email: haoran.tse@gmail.com
Tel: +86 18575536586

Cinaceptide is a synthetic 21-peptide used for the treatment of respiratory distress syndrome in preterm infants. Discovery Laboratories Inc is the original research company and was approved for marketing by the US FDA in March 2012.

The structure of Cinaceptide is as below:

Basic information
Chinese name: sinapritide
English name: Sinapultide
Company number: GT-F041
CAS Number: 138531-07-4
Sequence: H-Lys-Leu-Leu-Leu-Leu-Leu-Lys-Leu-Lys-Leu-Lys-OH
Formula: C126H238N26O22
Molecular weight: 2469.4

1. Preparation of Fmoc-Lys(Boc)-resin
1) Take 100g of 2-chloro-triphenyl chlororesin (0.5mmol/g resin, 50mmol), soak in 1000ml DMF for 30 minutes, make the resin fully swollen, add DIPEA 20ml, Fmoc-Lys(Boc)-OH 23.5g, 25°C for 65 minutes. Add 50ml of methanol and react at 25°C for 60 minutes.
2) Drain and dry, wash three times with DMF, methanol and DMF respectively, and drain dry.
2. Preparation of Fmoc-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
3. Preparation of Fmoc-Leu-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
4. Preparation of Fmoc-Leu-Leu-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
5. Preparation of Fmoc-Leu-Leu-Leu-Leu-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
6. Preparation of Fmoc-Lys(Boc)-Leu-Leu-Leu-Leu-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 70.5g of Fmoc-Lys(Boc)-OH, 57.0g HATU, and 20.5g HOAt, dissolve them with 520ml of peptide reagent, add them to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
7. Preparation of Fmoc-Leu-Lys(Boc)-Leu-Leu-Lys(Boc)-resin
1) Add 1000ml of uncapping reagent, react at 27-29°C for 15 minutes, drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
2) Take 74.2g of Fmoc-Leu-OH, 79.5g HATU, and 28.6g of HOAt, dissolve them with 760ml of leptide reagent, add them to the reaction vessel, and react at 19-21°C for 45 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
8. Preparation of Fmoc-Leu-Leu-Lys(Boc)-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
9. Preparation of Fmoc-Leu-Leu-Leu-Lys(Boc)-Leu-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
10. Preparation of Fmoc-Leu-Leu-Leu-Leu-Lys(Boc)-Leu-Leu-Leu-Leu-D-Tyr (tBu)-Resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
11. Preparation of Fmoc-Lys(Boc)-Leu-Leu-Leu-Leu-Leu-Lys(Boc)-Leu-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 70.5g of Fmoc-Lys(Boc)-OH, 57.0g HATU, and 20.5g HOAt, dissolve them with 520ml of peptide reagent, add them to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
12. Preparation of Fmoc-Lue-Lys(Boc)-Leu-Leu-Leu-Leu-Lys(Boc)-Leu-Lys(Boc)-resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
13. Preparation of Fmoc-Leu-Lue-Lys (Boc)-Leu-Leu-Leu-Leu-Lys(Boc)-Leu-Leu-Lys (Boc)-Resin
1) Add 1000ml of unhatting reagent, react at 21-23°C for 18 minutes, drain dry, wash with DMF, methanol and DMF three times each, and drain dry.
2) Take 53.0g Fmoc-Leu-OH, 57.0g HATU, and 20.5g HOAt, dissolve with 520ml of peptide reagent, add to the reaction vessel, and react at 0-5°C for 55 minutes.
3) Drain and wash three times with DMF, methanol and DMF respectively, and drain dry.
14. Preparation of Fmoc-Leu-Lue-Lue-Lys (Boc)-Leu-Leu-Leu-Leu

Anyone need enquiry about peptide synthesis, plz contact haoran.tse@gmail.com Tel: +8618575536586

If you're using GLP-1 receptor agonists (e.g., semaglutide, tirpotide, liraglutide, etc.) – these drugs that are effective in blood sugar control, weight management, and metabolic health, then a scientific nutritional intervention can take your results to the next level!
Why? Because GLP-1 drugs work by regulating appetite, delaying gastric emptying, and improving insulin sensitivity, they can also bring some challenges, such as muscle loss, micronutrient deficiencies, intestinal discomfort, etc. Reasonable nutritional supplementation can not only alleviate these side effects, but also enhance the effect of the drug, so that your health management can get twice the result with half the effort!
Today, we share five core nutritional supplements to provide comprehensive support for your GLP-1 treatment!

Protein powder: prevents muscle loss and maintains metabolic vitality

Why is it particularly important?
GLP-1 drugs significantly reduce appetite, which may lead to insufficient protein intake, while muscle loss can reduce basal metabolic rate, affecting long-term weight loss and physical performance.
Scientific Supplementary Scheme:
Whey protein (fast absorbing) or vegetable protein (easily digestible), 20-30g daily, can be added to breakfast or meals in portions.
The recommended daily protein intake for adults is 1.2-1.6g/kg body weight (for example, 60kg people, i.e., 60*1.2≈72g/day); If you have exercise habits, you can increase your body weight to 1.5-2.0g/kg to help muscle repair.
For example:
1 egg ≈ 6g protein
100g chicken breast ≈ 30g protein
100g tofu ≈ 8g protein
1 cup milk ≈ 8g protein

Fish oil (Omega-3):

Anti-inflammatory and heart-protecting, enhance insulin sensitivity
Key role: Users of GLP-1 often have a risk of metabolic syndrome.
Omega-3 (EPA+DHA) can:
✔ reduce systemic inflammatory response
✔ improve dyslipidemia (lower triglycerides)
✔ synergistic enhance insulin sensitivity
Precise supplementation suggestions:
Prioritize high-purity fish oil (EPA+DHA≥60%), with a daily intake of 1000-2000mg. Eating deep-sea fish (salmon, sardines) 2 to 3 times a week is a natural supplement.

Probiotics:

Optimizes gut health and relieves drug side effects
Necessity Analysis:
GLP-1 drugs may cause:
Gastrointestinal discomfort (nausea, bloating)
Imbalance of gut flora
Probiotics can:
Improves digestion and absorption
Enhances intestinal barrier function
Regulates the brain-gut axis (indirectly affects appetite)
Strain Selection Guidelines:
Focus on clinically validated strains such as Bifidobacterium lactis HN019 and Lactobacillus rhamnosus GG strain.
Supplement 100-30 billion CFU daily, recommended to take on an empty stomach before breakfast.

Cellulose:

Dual regulation of blood sugar and appetite
In-depth interpretation of the mechanism of action:
Soluble fiber (e.g., β-glucan, pectin): forms a gel to delay gastric emptying and prolongs satiety in synergy with GLP-1.
Insoluble fiber (e.g., cellulose, lignin): promotes intestinal motility and prevents constipation (common side effect of GLP-1).
Practical plan:
Total daily dose of 25-38 g, preferably from whole foods (oats, chia seeds, legumes).
Cellulose supplements, which can be gradually increased to avoid flatulence caused by sudden large intake.

Multivitamins & Minerals:

A critical line of defense to fill nutritional gaps
Risk warning:
The gastrointestinal effects of a low-calorie diet + GLP-1 can lead to:
Decreased absorption of vitamin B12
Insufficient vitamin D (affects weight loss)
Magnesium/zinc deficiency (associated with insulin resistance)
Targeted Supplementation Strategies:
Choose a multivitamin with active B12 (methylcobalamin).
Additional attention is paid to vitamin D3 (2000IU/day) and magnesium (200-400mg/day).

Tips：

Personalized adjustments are more effective!
✔ Consult a doctor/dietitian: adjust the dosage according to your own situation.
✔ Gradually: Cellulose and probiotics in particular to avoid gastrointestinal upset.
✔ Pair it with a balanced diet: high-quality protein + healthy fats + low GI carbohydrates for better results!

Any enquiries about Fish oil & Glucomannan ODM/OEM, vitamin B12 api
Plz contact haoran.tse@gmail.com
+8618575536586

Using Wegovy can be simple and straightforward with the correct guidance. While it's essential to follow the detailed instructions provided in the leaflet inside your medication box, here’s a step-by-step guide to make the process easier to follow.

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