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If you're using GLP-1 receptor agonists (e.g., semaglutide, tirpotide, liraglutide, etc.) – these drugs that are effective in blood sugar control, weight management, and metabolic health, then a scientific nutritional intervention can take your results to the next level!
Why? Because GLP-1 drugs work by regulating appetite, delaying gastric emptying, and improving insulin sensitivity, they can also bring some challenges, such as muscle loss, micronutrient deficiencies, intestinal discomfort, etc. Reasonable nutritional supplementation can not only alleviate these side effects, but also enhance the effect of the drug, so that your health management can get twice the result with half the effort!
Today, we share five core nutritional supplements to provide comprehensive support for your GLP-1 treatment!

Protein powder: prevents muscle loss and maintains metabolic vitality

Why is it particularly important?
GLP-1 drugs significantly reduce appetite, which may lead to insufficient protein intake, while muscle loss can reduce basal metabolic rate, affecting long-term weight loss and physical performance.
Scientific Supplementary Scheme:
Whey protein (fast absorbing) or vegetable protein (easily digestible), 20-30g daily, can be added to breakfast or meals in portions.
The recommended daily protein intake for adults is 1.2-1.6g/kg body weight (for example, 60kg people, i.e., 60*1.2≈72g/day); If you have exercise habits, you can increase your body weight to 1.5-2.0g/kg to help muscle repair.
For example:
1 egg ≈ 6g protein
100g chicken breast ≈ 30g protein
100g tofu ≈ 8g protein
1 cup milk ≈ 8g protein

Fish oil (Omega-3):

Anti-inflammatory and heart-protecting, enhance insulin sensitivity
Key role: Users of GLP-1 often have a risk of metabolic syndrome.
Omega-3 (EPA+DHA) can:
✔ reduce systemic inflammatory response
✔ improve dyslipidemia (lower triglycerides)
✔ synergistic enhance insulin sensitivity
Precise supplementation suggestions:
Prioritize high-purity fish oil (EPA+DHA≥60%), with a daily intake of 1000-2000mg. Eating deep-sea fish (salmon, sardines) 2 to 3 times a week is a natural supplement.

Probiotics:

Optimizes gut health and relieves drug side effects
Necessity Analysis:
GLP-1 drugs may cause:
Gastrointestinal discomfort (nausea, bloating)
Imbalance of gut flora
Probiotics can:
Improves digestion and absorption
Enhances intestinal barrier function
Regulates the brain-gut axis (indirectly affects appetite)
Strain Selection Guidelines:
Focus on clinically validated strains such as Bifidobacterium lactis HN019 and Lactobacillus rhamnosus GG strain.
Supplement 100-30 billion CFU daily, recommended to take on an empty stomach before breakfast.

Cellulose:

Dual regulation of blood sugar and appetite
In-depth interpretation of the mechanism of action:
Soluble fiber (e.g., β-glucan, pectin): forms a gel to delay gastric emptying and prolongs satiety in synergy with GLP-1.
Insoluble fiber (e.g., cellulose, lignin): promotes intestinal motility and prevents constipation (common side effect of GLP-1).
Practical plan:
Total daily dose of 25-38 g, preferably from whole foods (oats, chia seeds, legumes).
Cellulose supplements, which can be gradually increased to avoid flatulence caused by sudden large intake.

Multivitamins & Minerals:

A critical line of defense to fill nutritional gaps
Risk warning:
The gastrointestinal effects of a low-calorie diet + GLP-1 can lead to:
Decreased absorption of vitamin B12
Insufficient vitamin D (affects weight loss)
Magnesium/zinc deficiency (associated with insulin resistance)
Targeted Supplementation Strategies:
Choose a multivitamin with active B12 (methylcobalamin).
Additional attention is paid to vitamin D3 (2000IU/day) and magnesium (200-400mg/day).

Tips:

Personalized adjustments are more effective!
✔ Consult a doctor/dietitian: adjust the dosage according to your own situation.
✔ Gradually: Cellulose and probiotics in particular to avoid gastrointestinal upset.
✔ Pair it with a balanced diet: high-quality protein + healthy fats + low GI carbohydrates for better results!

Any enquiries about Fish oil & Glucomannan ODM/OEM, vitamin B12 api
Plz contact haoran.tse@gmail.com
+8618575536586

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A diabetes treatment drug called "Semaglutide" is rapidly gaining popularity due to its excellent weight loss results. Even Tesla CEO Elon Musk is full of praise for it, once revealing that the secret to losing 9 kilograms in a month is to fast and take semaglutide regularly.
Semaglutide Growth Trajectory:
In December 2017, the U.S. Food and Drug Administration (FDA) officially approved semaglutide injection for blood sugar control in adults with type 2 diabetes.
In September 2019, the US FDA approved Rybelsus (oral semaglutide) for medical use.
In January 2020, the FDA granted its new use approval again to reduce the risk of major adverse cardiovascular events in adult patients with type 2 diabetes mellitus with cardiovascular disease. In December of the same year, Novo Nordisk submitted a marketing application to the FDA for semaglutide 2.4mg subcutaneously once a week for weight loss.
In April 2021, the State Food and Drug Administration (NMPA) also approved its use in China for the treatment of type 2 diabetes in adults and to reduce the risk of cardiovascular adverse events in patients with T2DM and cardiovascular disease.
In June 2021, the FDA further approved it for the treatment of obesity, allowing semaglutide (Wegovy) injection to be used in adult obese individuals with a BMI of ≥30 or adults with a BMI of ≥27 with at least one weight-related condition, such as hypertension, type 2 diabetes, or dyslipidemia. Studies have shown that obese patients treated with semaglutide lose an average of 17%-18% of their weight over 68 weeks.
In January 2023, the FDA approved a new indication for Wegovy (semaglutide injection) for chronic weight management in pediatric patients with an age- and sex-adjusted initial body mass index (BMI) of 95% or more, 12 years of age and older, as an adjunct to low-calorie diets and increased physical activity. This is one of the few drugs in the world that is currently officially approved by the FDA for the treatment of obesity.
Oral semaglutide is highly regarded as the high-profile drug of the year. The following is a summary of several questions about semaglutide that everyone is most concerned about for reference.

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Enterokinase (EC3.4.21.9) belongs to serine proteases, produced by cells in the duodenal wall, and specifically recognizes and cleaves proteins or peptides-asp-asp-asp-asp-lys-↓-X. Natural bovine enterokinase contains a heavy chain of 800 amino acids and a light chain of 235 amino acids.
This product is a monoglycosylated form of bovine enterokinase light chain, recombinant expression by Pichia yeast and purified by high-performance chromatography, containing 6 His-tags, theoretical molecular weight of about 43 kDa, optimal digestion pH of 4.5-9.5, and optimal digestion temperature of 25°C. Recombinant interic kinase activity is inhibited to varying degrees by imidazole, sodium chloride, glycerin, phosphate, etc.
rEK applications:

  1. Due to the high specificity and high hydrolysis efficiency of enterokinase, it is widely used in the development of genetic engineering products. It can specifically recognize and cleave substrates containing the enterokinase cleavage site DDDDK- as a protease, and one of its applications is as a tool protease for specific breakage of recombinant fusion proteins, especially in the bioengineering pharmaceutical industry and research in genetic engineering, biochemistry, molecular biology, etc. [2].
  2. Enterokinase can be solidified, more effective in cleaving fusion proteins, and maintaining higher activity of enterokinase, which is conducive to reducing the production cost of biological drugs [3].
  3. Scientific research use: fusion tag excision of recombinant expressed proteins; Activation of trypsinogen.

For any enquiries about P29/diapeptides/side chain/semaglutide api/tirzepatide api, plz feel free to contact me.
Tel: +8618575536586
Email: haoran.tse@gmail.com

Introduction for Carboxypeptidase B
Carboxypeptidase B (E.C. 3.4.17.2) was first discovered and isolated by Folk in 1960 in the pancreas of pigs and cattle. It is a class of digestive enzymes that can hydrolyze the substrate C-terminal arginine and lysine, synthesized in the form of inactive enzymes in the pancreas, each molecule contains a Zn atom, selectively hydrolyzed proteins and amino acids containing the carboxyl terminus of the polypeptide, its basic function is to decompose the peptides produced by trypsin degradation proteins, because the hydrolyzed amino acids are basic amino acids, carboxypeptidase B was initially named alkaline carboxypeptidase, in order to distinguish it from the earlier discovery of carboxypeptidase A, and finally renamed it carboxypeptidase B. Alkaline carboxypeptidase is also found in other tissues, such as the liver, lungs, intestines, brain, etc. [1].
Our carboxypeptidase B is recombinant expression by Pichia yeast without any tags, the theoretical molecular weight is 35kDa, the optimal digestion pH is 7.5~8.5, and the optimal digestion temperature is 37°C>. At a certain temperature (<60°C), enzyme cleavage activity can increase with increasing temperature. Recombinant carboxypeptidase B activity was inhibited by metal chelating agents such as EDTA, Cu2+, and Hg2+, while metal ions such as Zn2+ and Mn2+ could increase enzyme activity to varying degrees.
Applications of carboxypeptidase B
In the field of medical pharmaceuticals, CPB has the biological characteristic of preferentially cutting basic amino acids, so it can be used in the production of recombinant insulin products and participate in the digestion of proinsulin as an important tool enzyme [2]. 02Food manufacturing In the field of food manufacturing, it can be used to prepare high F-value oligopeptides.
the removal of ochratmycin from food and feed and the debittering of soybean protein hydrolysate [3].
In the field of biotechnology, carboxypeptidase B can be used to determine the synthesis of peptides and the amino acid sequence of peptides, and can also be used as a specific model enzyme, such as the design of zinc protease-specific inhibitors, to provide relevant help to other types of enzymes.
Our advantages:
High purity and high specific activity.
Good stability: Freeze-dried powder, easy to store and transport.
No animal origin: recombinant production, no exogenous virus contamination, no animal origin raw materials are used in the production process.
3,000L fermentation scale under the GMP quality management system: the batch output scale is large and the batch consistency is high, and the batch output can reach 500-1,000g, which can meet the quality requirements of scientific research customers and the requirements of industrialization customers for product quality, output and GMP conditions during industrialization.
Complete quality documentation: Relevant regulatory support documents can be provided according to customer needs.
A matching carboxypeptidase B content detection kit can be provided at the same time.

For any enquiries about P29/diapeptides/side chain/semaglutide api/tirzepatide api, plz feel free to contact me.
Tel: +8618575536586
Email: haoran.tse@gmail.com